During the Xin Dynasty, Liu Xiu met Deng Yu, Liu Xuan, Feng Yi and other young talents and Yin Lihua in his childhood when he was studying at the Imperial College in Chang'an. A few years later, the Xinmang tyranny caused chaos in the world. Liu Xiu followed his brother Liu Yan to rise up, and Yin Lihua also disguised herself as Yin Ji and followed him. From the Chongling Uprising to the Battle of Kunyang, Liu Xiu fought side by side with a group of comrades who were loyal to each other and fought bloody battles. Unexpectedly, after Liu Xuan became emperor, he was afraid of the great achievements of the Liu brothers and killed Liu Yan. Liu Xiu married Yin Lihua as his wife, kept a low profile, and let Liu Xuan relax his vigilance, let him hold the festival and go north to revitalize the army. The road to Hebei was full of crises, but fortunately Deng Yu, Feng Yi, Wu Han, Geng Yan and other old and new acquaintances came one after another to share weal and woe. Liu Yang, the King of Zhending in Hebei, proposed a marriage alliance. In order to take the overall situation into consideration, Liu Xiu reluctantly separated from his wife. Afterwards, Liu Xiu joined forces with Deng Yu and Feng Yi, and after decades of unremitting efforts, ended the war, pacified Hebei and other areas, established Luoyang as the capital, established the Eastern Han Dynasty, and finally fulfilled their common wish.