At the end of the 19th century, the sky over London, England was overcast. Explorer Sir Malcolm Murray (Timothy Dalton) and beautiful psychic Vanessa Ives (Eva Green) are looking for his daughter Mina. In the process of fighting with a group of unidentified creatures, they seem to have glimpsed the secrets of ancient Egypt two thousand years ago. Genius surgeon Victor Frankenstein (Harry Treadaway) created Frankenstein with corpses. When he experienced the fun of the Creator, he was also bound by the shadow of the past. Ethan Chandler (Josh Hartnett), an American down-and-out boy who is looking for a performance, was hired by Vanessa because of his excellent marksmanship. His incredible experience made him linger in London and difficult to escape. During this period, he fell in love with the miserable woman * Billie Piper (Billie Piper). These people came together for various reasons and faced the nightmare that they could never get rid of together...