Under the leadership of the Duke (Channing Tatum), the special forces dealt a heavy blow to the terrorist organization "Cobra". Although the Cobra commander and other key figures were arrested, the backbone of the organization such as White Ghost (Lee Byung-hun) is still at large, ready to launch a counterattack against the special forces and the world at any time. After the nuclear crisis in a Middle Eastern country was solved cleanly, the special forces suddenly suffered a tragic blow from the US government. The Duke and other team members died heroically. Only Roadblock (Dwayne Johnson), Miss Jay (Adrianne Palicki) and Flynn (DJ Cotrona) escaped by chance. It turns out that Cobra has already infiltrated the top level of the United States. They used this to discredit the special forces and frame Snake Eyes, one of the important members, in order to find and rescue the imprisoned commander. The three roadblocks, who are nominally "dead", must try every possible means to stop Cobra's evil plan and redeem the reputation of their dead comrades and the special forces...