In 2599, the Mars immigration plan that humans have been planning for 500 years is finally about to take an important step. Prior to this, scientists have improved the living environment of Mars by placing algae and cockroaches on Mars. Now, in order to avoid the punishment of the death penalty, Komachi Kokichi (played by Ito Hideaki) and childhood sweetheart Akita Nanao (played by Takei Saki) have to agree to Dr. Honda's (played by Oguri Shun) request, and people with different identities and backgrounds such as Muto Jin (played by Yamashita Tomohisa), Hiruma Ichiro (played by Yamada Takayuki), Moriki Asuka (played by Kikuchi Rinko), and Dojima Keisuke (played by Kato Masaya) stepped into the spacecraft to Mars. After arriving at the destination, they were surprised to find that the cockroaches had already evolved into extremely strong and tall creatures, and quickly attacked them. During the battle, they learned the real purpose of this trip to Mars, so they tried their best to fight the flood of cockroaches in order to return to Earth...