The story continues from the previous one. Yanke (Channing Tatum) and Schmidt (Jonah Hill) finally "smoothly graduated" from high school, but what awaits them is another round of undercover operations. This time, the target they have to challenge is "college". Compared with high school, the complexity of interpersonal relationships and the difficulty of coursework in college are much higher. This time, can the two brothers successfully complete the task? In the academy, Yanke joined the school football team and met a group of like-minded friends. At the same time, Schmidt chose to study in the art department and had a romantic anecdote with the quirky Maya (Amber Stevens). However, the rich and wonderful college life caused a rift between Yanke and Schmidt, who were inseparable, and the huge rift may cause the two who shared weal and woe to eventually part ways.