Sally (Meg Ryan) drove Harry (Billy Crystal) to New York, and the two met. On the way, the two had a disagreement and parted unhappily, leaving behind the classic question: "Excluding the involvement of 'sex', can men and women be true friends?" Five years later. The two met unexpectedly at the airport. At this time, Sally was immersed in the sweetness of her new relationship, and Harry was about to enter a formal married life. Harry told Sally: "When two people love each other, men and women may become friends, but soon they will question why they are dating people who can only be friends." Sally left with her sleeves. Ten years later. Sally, who was heartbroken, met Harry, who had just divorced, again. Harry said to Sally: "Are we going to be friends? You may be the first charming woman I don't want to take to bed." The phone call before going to bed, spending Christmas together, and making suggestions for each other's feelings, Harry and Sally have an indescribable tacit understanding. However, is this really the beginning of a beautiful friendship? Or is this quietly coming a mistaken relationship...