In the second season, the pair of Nasuda Ayumu (Okada) and Kuki Shizuka (Nakai) descended into the increasingly chaotic Japanese medical world under the wave of "work style reform". In addition to the shortage of doctors, overtime hours for doctors and nurses are also greatly restricted, and they challenge new battles in the shrinking life scene. This time, Ayumu and Shizuka were employed by the "Nishi-Tokyo General Hospital", a backbone hospital that has long served as the core of regional medicine. After the corruption of the former director of the hospital was discovered, the "clean, young and charismatic new director" who advocated "correct medical care, correct work style" embarked on organizational changes centered on work style reform, and continuously promoted task sharing, thorough service management, and medical visualization. But this new director is "the biggest enemy of this season." Soon, Ayumu and Shizuka confronted the new director.